Cell therapy offers a disease-modifying option for patients w/ refractory autoimmune disease.
Autoimmune disease is a major unmet need
Est. 7M patients in the U.S. with a form of B-cell mediated autoimmune disease (Canaccord Genuity, 2023)
Pathogenic B cells can drive systemic diseases via intrinsic/extrinsic factors.
The effectiveness of current therapies is inadequate:
Often consists of lifelong immune suppression
B-cell-directed agents have limited activity
Recent results with CD19 CAR-T in treating auto-immune diseases look promising
CD19-directed cell therapy is challenging the treatment paradigm for autoimmune diseases
Drug-free remissions after a single treatment in academic trials.
⇨ See below for Mackensen et al. 2022 and Muller 2023 results in lupus (FIG. 1 📸).
FIG. 1. CD19-directed Cell Therapy Potential (early results in autoimmune disease).
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Article History:
02/08/24-EJV
This article is not investment or legal advice.
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